A Nanoplatform Based on Pillararene Nanovalves for Combined Drug Delivery and Enhanced Antitumor Activity

Modern nanodrug delivery technologies offer new approaches in the fight against cancer. However, due to the heterogeneity of tumors and side effects of anticancer drugs, monotherapies are less effective. Herein, we report a novel pH and light dual‐responsive nanodrug delivery platform. The platform...

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Bibliographic Details
Published in:Chemistry : a European journal 2024-03, Vol.30 (13)
Main Authors: Jiang, Jianfeng, Su, Zhilian, He, Qin, Duan, Wengui, Huang, Yan, Liu, Luzhi
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic drugs
Antitumor activity
Biocompatibility
Cancer
Cancer therapies
Chemotherapy
Controlled release
Doxorubicin
Drug delivery
Glucose oxidase
Gold
Heterogeneity
Hydrogen peroxide
Irradiation
Light irradiation
Nanoparticles
Photothermal conversion
Side effects
Sulfonic acid
Sustained release
Tumor cells
Tumor suppression
Tumors
Wavelengths
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Summary:Modern nanodrug delivery technologies offer new approaches in the fight against cancer. However, due to the heterogeneity of tumors and side effects of anticancer drugs, monotherapies are less effective. Herein, we report a novel pH and light dual‐responsive nanodrug delivery platform. The platform was formed by sulfonate‐modified gold nanoparticles loaded with the anticancer drugs doxorubicin (DOX) and glucose oxidase (GOx) and then covered by water‐soluble pillar[5]arene as a nanovalve. The nanovalve formed by the host‐guest interaction between pillar[5]arene and the sulfonic acid group grafted onto the gold nanoparticle increased the drug loading capacity of the nanoplatform and enabled sustained release of the drug in a simulated weakly acidic tumor environment. The released GOx can consume intracellular glucose, namely, starvation therapy, while the generated hydrogen peroxide can further kill tumor cells, complementing DOX chemotherapy. Gold nanoparticles have good photothermal conversion ability and can enhance the drugs release rate under specific wavelengths of light irradiation. The results of in vitro and in vivo experiments showed that this novel nanodrug delivery platform has good biocompatibility and better therapeutic efficacy relative to monotherapy. This study successfully developed a combined chemo/starvation therapy strategy with good tumor suppression, providing a new approach for cancer treatment.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202400007