Glutathione-Responsive T1 Contrast Agent for Tumor Imaging

Tumor microenvironment responsive probe holds great potential to achieve precise diagnosis owning to its capacity to show different signal in tumor and normal tissue. Here, we develop an intelligent magnetic resonance imaging (MRI) contrast agent (CA) with the capacity to rapidly respond to GSH. Thi...

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Bibliographic Details
Published in:Applied magnetic resonance 2024-04, Vol.55 (4), p.387-397
Main Authors: Wang, Xueqin, Ye, Xi, Qin, Xiaoping, Fu, Yi, Tang, Hong
Format: Article
Language:English
Subjects:
Acids
Atoms and Molecules in Strong Fields
Biocompatibility
Contrast agents
Decomposition
Diagnosis
Electrons
Ethanol
Glutathione
Laser Matter Interaction
Magnetic fields
Magnetic resonance imaging
Manganese ions
Medical imaging
Nanoparticles
Organic Chemistry
Original Paper
Physical Chemistry
Physics
Physics and Astronomy
Polyethylene glycol
Scanners
Solid State Physics
Spectroscopy/Spectrometry
Spectrum analysis
Toxicity
Tumors
Citations: Items that this one cites
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Description
Summary:Tumor microenvironment responsive probe holds great potential to achieve precise diagnosis owning to its capacity to show different signal in tumor and normal tissue. Here, we develop an intelligent magnetic resonance imaging (MRI) contrast agent (CA) with the capacity to rapidly respond to GSH. This intelligent MRI CA keep in “off” state in normal tissue while degrade into manganese ions and exhibit “on” state in tumor lesion. This unique feature endows this activable MRI CA to fulfill accurate tumor detection. Besides, this intelligent CA show negligible cytotoxicity to cell and mice, indicating its excellent biocompatibility and immense potential to biological application. This work develops a new activable MRI CA to sensitively detect tumor and provides guidelines to design new activable MRI CA for precise diagnosis.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-023-01629-5