Cobalt‐Catalyzed Oxytrifluoromethylation of N‐Allylamides toward Trifluoromethyl‐Containing Oxazolines

We herein report a cobalt‐catalyzed intramolecular oxytrifluoromethylation of N‐allylamides for the efficient synthesis of trifluoromethyl‐containing oxazolines with Togni's reagent II as the trifluoromethyl precursor. The protocol features mild reaction conditions and good functional group com...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2024-03, Vol.13 (3), p.n/a
Main Authors: Han, Jun‐Fa, Gao, Fang‐Ling, Chen, Lin, He, Zi‐Xin, Lin, Yuqi, Ye, Ke‐Yin
Format: Article
Language:English
Subjects:
cobalt catalysis
Free radicals
Functional groups
N-allylamides
oxazolines
oxytrifluoromethylation
Reagents
Togni's reagent II
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Summary:We herein report a cobalt‐catalyzed intramolecular oxytrifluoromethylation of N‐allylamides for the efficient synthesis of trifluoromethyl‐containing oxazolines with Togni's reagent II as the trifluoromethyl precursor. The protocol features mild reaction conditions and good functional group compatibility. Preliminary mechanistic investigations suggest the involvement of free radicals in this transformation. A cobalt‐catalyzed intramolecular oxytrifluoromethylation of N‐allylamides and Togni's reagent II was reported toward the efficient synthesis of diverse trifluoromethyl‐containing oxazolines.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202300579