Autologous Platelets-Rich Plasma Gel Promotes Neo-Vascularization and Re-Epithelization in Cutaneous Wound Healing in Rescued Horses

ABSTRACT Autologous platelet-rich plasma (PRP) gel has been suggested for wound repair. However, there is insufficient evidence to support its usage in animals with cutaneous wounds. Therefore, this study aimed to evaluate the effect of PRP gel on cutaneous wound healing in rescued horses. Twelve ho...

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Bibliographic Details
Published in:Pakistan journal of zoology 2024-04, Vol.56 (2), p.579
Main Authors: Sajjad, Muhammad Talha, Akbar, Hamid, Khan, Muhammad Arif, Mushtaq, Muhammad Hassan, Bokhari, Shehla Gul, Hayat, Muhammad Abid, Mustafa, Ghulam
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Blood platelets
Care and treatment
Color
Cruelty to animals
Cytokeratin
Cytokines
Diagnosis, Ultrasonic
Doppler effect
Fibroblasts
Growth factors
Health aspects
Horses
Physiological aspects
Plasma
Platelet-rich plasma
Platelets
Staining
Ultrasonic imaging
Vascularization
Wound healing
Wounds and injuries
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Summary:ABSTRACT Autologous platelet-rich plasma (PRP) gel has been suggested for wound repair. However, there is insufficient evidence to support its usage in animals with cutaneous wounds. Therefore, this study aimed to evaluate the effect of PRP gel on cutaneous wound healing in rescued horses. Twelve horses were divided into two groups: group A (PRP-treated) and group B (control). The group A (n=6) animals were treated with autologous PRP gel, while the group B (n=6) animals were treated with sterile saline. Full-thickness (3 x 3 cm2) skin wounds were selected in each horse on either left or right region of back. Neovascularization was assessed on days 14 and 28 by color Doppler ultrasonography and cytokeratin staining. Wound re-epithelialization and the number of fibroblasts were assessed by cytokeratin staining. All data were statistically analyzed. We observed that PRP-wounds had highly significantly (P
ISSN:0030-9923
0030-9923
DOI:10.17582/journal.pjz/20220717180718