Vascular Inflammation Attributed by IL-6 and Thrombomodulin in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Visiting a Local Hospital

• Published in: Pakistan journal of zoology 2024-04, Vol.56 (2), p.793
• Main Authors: Shahida, Rehana, Naz, Shagufta, Farasat, Tasnim, Sharif, Saima, Jahan, Shah, Manzoor, Farkhanda
• Format: Article
• Language: English
• Subjects: Arteriosclerosis; Atherosclerosis; Blood pressure; Body mass index; Body size; Cardiovascular diseases; Cholesterol; Cytokines; Damage tolerance; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Endothelium; Glucose; Glucose tolerance; Health aspects; High density lipoprotein; Hyperglycemia; Impact damage; Inflammation; Insulin; Insulin resistance; Interleukin 6; Lipids; Measurement; Membrane proteins; Parameters; Physiological aspects; Proteins; Serum levels; Socioeconomics; Statistical analysis; Thrombomodulin; Triglycerides; Tumor necrosis factor-TNF; Type 2 diabetes; Variance analysis
• ISSN: 0030-9923; 0030-9923
• DOI: 10.17582/journal.pjz/20220820160858

ABSTRACT Diabetes mellitus type 2 (T2DM) is linked to a higher risk of atherosclerotic cardiovascular disease. The development and outcome of atherosclerosis are both influenced by vascular inflammation. The main purpose of this study is to find the impact of Interleukin-6 (IL-6) and thrombomodulin on vascular damage in the patients having impaired glucose tolerance (IGT) and to identify the relationship of IL-6 with insulin resistance. The patients visiting Amin Hayat Memorial Diabetic Center, Lahore from (January 2017 to October 2017) the subjects following WHO criteria of IGT and Diabetes were included. Demographic parameters as age, body mass index, waist/hip ratio, blood pressure, and socioeconomic status were recorded. Proatherogenic parameters like plasma glucose level, serum levels of insulin, thrombomodulin and IL-6 were measured by ELISA. The serum level of thrombomodulin was assessed as a measure of vascular damage. This study showed significantly elevated serum concentration of IL-6 and altered lipid profile in diabetes individual when compared with the control subjects. IL-6 and thrombomodulin was progressively higher in diabetic group. IL-6 correlated positively with thrombomodulin in the control group but an inverse association was seen in the IGT group and revealed that imbalance of the vascular damage initiated and that lead to damage of vascular endothelium in diabetes.