Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity – A Pilot Study: Part 1 – Laparoscopic Greater Curvature Plication

• Published in: Physiological research 2023, Vol.72, p.S399-S403
• Main Authors: Metelcová, T, Hainer, V, Hill, M, Kalousková, P, Vrbíková, J, Šrámková, P, Fried, M, Taxová Braunerová, R, Kunešová, M
• Format: Article
• Language: English
• Subjects: Antidiabetics; Body composition; Body mass index; Cardiovascular disease; Diabetes; Diabetes mellitus (non-insulin dependent); Endocrinology; Gastrointestinal surgery; Glucose; Health risk assessment; Health risks; Hyperglycemia; Insulin; Investigations; Laparoscopy; Long-term effects; Metabolism; Obesity; Pilot projects; Plasma; Surgery; Triglycerides; Weight control; Womens health
• ISSN: 0862-8408; 1802-9973
• DOI: 10.33549/physiolres.935145

The long-term effects of bariatric surgery on postprandial profiles in patients with obesity and type 2 diabetes (T2D) have not yet been investigated. Therefore, this study examined postprandial profiles before laparoscopic greater curvature plication (LGCP), and then at 2 and 10 years after surgery.The studied cohort included 10 women (mean age= 54.4±5 years) with obesity (mean BMI= 42.5±7.8 kg/m²) and T2D who underwent LGCP. All subjects underwent a standardized liquid mixed-meal test. For statistical evaluation, ANOVA with Bonferroni multiple comparison was used. Mean postprandial levels were significantly decreased 2 years after surgery. Responses 10 years after the surgery also remained significantly lower than before surgery. Changes observed during the follow-up were significant: glucose: F=34.5, p