Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats

The Akar kuning (Fibraurea tinctoria Lour) is a well-known plant for its potential for the treatment of liver damage and hyperglycemia. However, the main constituent responsible for the anti-diabetic effect is unknown. This study was conducted to investigate the effect of administration of Fibraurea...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2024-01, Vol.17 (1), p.379-384
Main Authors: Supomo, Supomo, Siswanto Syamsul, Eka, Saadah, Hayatus, Kintoko, Kintoko, Astuti Witasari, Hardi
Format: Article
Language:English
Subjects:
Animals
Antidiabetics
Diabetes
Ethanol
Glucose
Hyperglycemia
Insulin
Metabolism
Metabolites
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Summary:The Akar kuning (Fibraurea tinctoria Lour) is a well-known plant for its potential for the treatment of liver damage and hyperglycemia. However, the main constituent responsible for the anti-diabetic effect is unknown. This study was conducted to investigate the effect of administration of Fibraurea tinctoria Lour ethanol extract on the blood sugar levels in alloxan-induced diabetic male albino rats. All animals were acclimatized with normal feed, and were subsequently divided into 5groups (3rats/ group). Group 1 (negative control group) was given 0.3% NaCMC; Groups 2, 3, and 4 (treatment groups), were given 50, 100, and 200mg/kg BW of Fibraurea tinctoria Lour ethanol extract, respectively once daily for 15 days, while Group 5(positive control group) received 0.65mg/kg BW glibenclamide. Before the treatments, the rats were induced intraperitoneally with 175mg/kg BW alloxan monohydrate. The blood glucose levels were observed every five days. The results showed that the ethanol extract at the doses of 50, 100, and 200mg/kg BW caused a significant decrease (p
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2024.00059