A microneedle patch realizes weight loss through photothermal induction of fat browning

As a globally prevalent disease, obesity leads to many chronic diseases, so it is important to develop safe and effective treatments with fewer side effects and lasting weight loss. In this study, we developed a biodegradable hyaluronic acid microneedle patch loaded with polydopamine nanoparticles a...

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Bibliographic Details
Published in:Biomaterials science 2024-03, Vol.12 (7), p.1726-1737
Main Authors: Gao, Zichun, Liu, Yixuan, Lin, Wenjiao, Lian, He, Meng, Zhaoxu
Format: Article
Language:English
Subjects:
Acetanilides
Adipose tissue
Animals
Biocompatibility
Browning
Hyaluronic acid
Mice
Mice, Inbred C57BL
Mice, Obese
Needles
Obesity - drug therapy
Side effects
Thiazoles
Weight Loss
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Summary:As a globally prevalent disease, obesity leads to many chronic diseases, so it is important to develop safe and effective treatments with fewer side effects and lasting weight loss. In this study, we developed a biodegradable hyaluronic acid microneedle patch loaded with polydopamine nanoparticles and mirabegron, which directly acted on subcutaneous white adipose tissue, and then induced browning of white adipose tissue through mild photothermal therapy. The approach showed excellent browning-promoting ability and biocompatibility. It is noteworthy that the weight of untreated mice increased by 9%, while the weight of obese mice decreased by nearly 19% after photothermal treatment. In addition, when mirabegron was used in combination with photothermal therapy, the weight loss of obese mice was more significant, with a weight loss of about 22%. This microneedle patch exhibited attractive potential for body slimming. Hyaluronic acid microneedles loaded with polydopamine nanoparticles induce fat browning, offering innovative localized obesity treatment.
ISSN:2047-4830
2047-4849
DOI:10.1039/d3bm01767b