Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment

Almost all cancer treatments are significantly limited by the strong tumor microenvironment (TME) fortress formed by abnormal vasculature, dense extracellular matrix (ECM), multidrug resistance (MDR) system, and immune “cold” environment. In the huge efforts of dismantling the TME fortress, nitric o...

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Bibliographic Details
Published in:Advanced functional materials 2024-03, Vol.34 (13)
Main Authors: Xiang, Yuting, Chen, Qiaohui, Nan, Yayun, Liu, Min, Xiao, Zuoxiu, Yang, Yuqi, Zhang, Jinping, Ying, Xiaohong, Long, Xingyu, Wang, Shuya, Sun, Jian, Huang, Qiong, Ai, Kelong
Format: Article
Language:English
Subjects:
Biological effects
Biological properties
Dismantling
Fortresses
Immunosuppression
Low temperature resistance
Nitric oxide
Tumors
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Summary:Almost all cancer treatments are significantly limited by the strong tumor microenvironment (TME) fortress formed by abnormal vasculature, dense extracellular matrix (ECM), multidrug resistance (MDR) system, and immune “cold” environment. In the huge efforts of dismantling the TME fortress, nitric oxide (NO)‐based nanomedicines are increasingly occupying a central position and have already been identified as super “strong polygonal warriors” to dismantle TME fortress for efficient cancer treatment, benefiting from NO's unique physicochemical properties and extremely fascinating biological effects. However, there is a paucity of systematic review to elaborate on the progress and fundamental mechanism of NO‐based nanomedicines in oncology from this aspect. Herein, the key characteristics of TME fortress and the potential of NO in reprogramming TME are delineated and highlighted. The evolution of NO donors and the advantages of NO‐based nanomedicines are discussed subsequently. Moreover, the latest progress of NO‐based nanomedicines for solid tumors is comprehensively reviewed, including normalizing tumor vasculature, overcoming ECM barrier, reversing MDR, and reactivating the immunosuppression TME. Lastly, the prospects, limitations, and future directions on NO‐based nanomedicines for TME manipulation are discussed to provide new insights into the construction of more applicable anticancer nanomedicines.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202312092