Eosinophilic Pneumonia Induced by Daptomycin

Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare but serious complication associated with the use of this broad-spectrum antibiotic. We present the case of a teenager with a history of nasopharyngeal cancer who developed DIEP while receiving daptomycin to treat an infection associated with...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-02, Vol.16 (2), p.e55095
Main Authors: Ayala Torres, Sr, Juan D, Noreña, Brian, Suarez Poveda, Alma Tatiana
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Chemotherapy
Disease
Dyspnea
Gram-positive bacteria
Lavage
Patients
Pneumonia
Radiation therapy
Staphylococcus infections
Thrombosis
Tomography
Tumors
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Summary:Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare but serious complication associated with the use of this broad-spectrum antibiotic. We present the case of a teenager with a history of nasopharyngeal cancer who developed DIEP while receiving daptomycin to treat an infection associated with an implanted chamber catheter. Symptoms included recurrent dyspnea and peripheral eosinophilia, with radiological findings consistent with DIEP. The pathophysiology involves an immune response triggered by daptomycin, resulting in eosinophilic pulmonary inflammation. Diagnosis requires a thorough evaluation of medical history, clinical laboratory tests, and radiological findings. The main treatment involves discontinuation of daptomycin and, in severe cases, the use of steroids. It is essential to consider DIEP in patients with respiratory failure and bilateral pulmonary opacities who have used daptomycin and to suspect it in those with blood eosinophilia or in bronchoalveolar lavage.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.55095