Plant based food bioactives: A boon or bane for neurological disorders

Neurological disorders are the foremost occurring diseases across the globe resulting in progressive dysfunction, loss of neuronal structure ultimately cell death. Therefore, attention has been drawn toward the natural resources for the search of neuroprotective agents. Plant-based food bioactives h...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2024, Vol.64 (11), p.3279-3325
Main Authors: Choudhary, Neeraj, Tewari, Devesh, Nabavi, Seyed Fazel, Kashani, Hamid Reza Khayat, Lorigooini, Zahra, Filosa, Rosanna, Khan, Farheen Badrealam, Masoudian, Nooshin, Nabavi, Seyed Mohammad
Format: Article
Language:English
Subjects:
Apoptosis
Bioactives
Biological activity
Cell death
Clinical trials
Excitotoxicity
Food
Health services
Humans
In vivo methods and tests
Inflammation
Information flow
mechanism
Natural resources
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neurological diseases
Neurological disorders
Neuroprotection
Neuroprotective agents
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Oxidative Stress
Plant-based foods
preclinical
Prevention
targets
Therapeutic targets
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Summary:Neurological disorders are the foremost occurring diseases across the globe resulting in progressive dysfunction, loss of neuronal structure ultimately cell death. Therefore, attention has been drawn toward the natural resources for the search of neuroprotective agents. Plant-based food bioactives have emerged as potential neuroprotective agents for the treatment of neurodegenerative disorders. This comprehensive review primarily focuses on various plant food bioactive, mechanisms, therapeutic targets, in vitro and in vivo studies in the treatment of neurological disorders to explore whether they are boon or bane for neurological disorders. In addition, the clinical perspective of plant food bioactives in neurological disorders are also highlighted. Scientific evidences point toward the enormous therapeutic efficacy of plant food bioactives in the prevention or treatment of neurological disorders. Nevertheless, identification of food bioactive components accountable for the neuroprotective effects, mechanism, clinical trials, and consolidation of information flow are warranted. Plant food bioactives primarily act by mediating through various pathways including oxidative stress, neuroinflammation, apoptosis, excitotoxicity, specific proteins, mitochondrial dysfunction, and reversing neurodegeneration and can be used for the prevention and therapy of neurodegenerative disorders. In conclusion, the plant based food bioactives are boon for neurological disorders.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2022.2131729