Adenosquamous carcinoma of the vulva: Rare tumor with unusual clinical presentation

A 52‐year‐old female presented with labial ulcer of 4‐month duration. Examination showed 1 cm × 1 cm single superficial ulcer in the right labium majus. Excision was done, and histopathologic examination revealed surface ulceration and dermal invasion by epithelial neoplasm formed of biphasic prolif...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2024-05, Vol.51 (5), p.329-331
Main Authors: El Hanbuli, Hala M., Sarie, Mostafa A. Abou, Ibrahium, Gehan Azoz, Al‐Amaragy, Amr, Elsonbaty, Mostafa
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenosquamous
Carcinoembryonic antigen
Carcinoma, Adenosquamous - pathology
Carcinoma, Squamous Cell - pathology
Cell proliferation
Female
Humans
immunohistochemistry
Middle Aged
Neoplasia
skin cancer
Skin Neoplasms - pathology
Squamous cell carcinoma
Ulcer
Vulva - pathology
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Summary:A 52‐year‐old female presented with labial ulcer of 4‐month duration. Examination showed 1 cm × 1 cm single superficial ulcer in the right labium majus. Excision was done, and histopathologic examination revealed surface ulceration and dermal invasion by epithelial neoplasm formed of biphasic proliferation of squamoid and gland‐forming cells. Immunohistochemical staining with p63 showed nuclear staining of the squamoid nests and was negative in areas with glandular differentiation, while epithelial membrane antigen and carcinoembryonic antigen highlighted the glandular elements. The case was diagnosed as primary cutaneous adenosquamous carcinoma (ASC). ASC is an uncommon malignant cutaneous neoplasm that is more aggressive than conventional squamous cell carcinoma. There are a few reports of ASC that presented as an erythematous papule or plaque with a preference for the head, neck, or upper extremities. We report a novel case of vulval ASC presented as a superficial ulcer, which is considered a unique site, and its clinical presentation.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14587