Supramolecular systems based on 2-hydroxyethylpiperidinium surfactants and Brij® 35: aggregation behavior, solubilization properties, and antimicrobial activity

The aggregation behavior of mixed micellar solutions based on 2-hydroxyethylpiperidinium surfactants and nonionic surfactant Brij® 35 was investigated. The critical micelle concentrations determined by varying the component ratio suggest a negative deviation from the ideal mixing model (synergistic...

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Bibliographic Details
Published in:Russian chemical bulletin 2024-03, Vol.73 (3), p.536-545
Main Authors: Kushnazarova, R. A., Mirgorodskaya, A. B., Bekrenev, D. D., Lyubina, A. P., Lenina, O. A., Petrov, K. A., Voloshina, A. D., Zakharova, L. Ya
Format: Article
Language:English
Subjects:
Binary systems
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deviation
Full Articles
Inorganic Chemistry
Micelles
Organic Chemistry
Solubilization
Surfactants
Synergistic effect
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Summary:The aggregation behavior of mixed micellar solutions based on 2-hydroxyethylpiperidinium surfactants and nonionic surfactant Brij® 35 was investigated. The critical micelle concentrations determined by varying the component ratio suggest a negative deviation from the ideal mixing model (synergistic effect). It was demonstrated that the magnitude of the deviation from ideal mixing behavior depends on the alkyl chain length in the cationic surfactant and on the component ratio. The solubilization effect of the binary systems on hydrophobic substances was evaluated taking Orange OT dye and ibuprofen drug as examples. It was found that the piperidinium surfactants studied, both individually and in compositions containing up to 50% of the nonionic surfactant, exhibit high antimicrobial activity comparable to that of commercial antibiotics.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4163-4