RETRACTED ARTICLE: Development ofElectrochemical Immunosensors for Early Diagnosis of Polycystic Ovary Syndrome (PCOS),and Their Potential Mobile Phone Application

An effective way of monitoring the biomarker is with electrochemical sensor studies. In this work, it was formed using electrochemical deposition of high conductivity gold nanoparticles (AuNPs) and an amine-functional reduced graphene oxide (NH2-RGO) nanocomposite. This technique not only reduced HA...

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Bibliographic Details
Published in:Topics in catalysis 2024-01, Vol.67 (9-12), p.688-697
Main Authors: Al-Janabi Muhammad Ali Yousif, Bayat Ramazan, Bekmezci Muhammed, Elhouda Tiri Rima Nour, Sen, Fatih, Kaffash Afsaneh, Baghayeri Mehdi, Rokni Hassan, Karimi Fatemeh
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Chemical sensors
Crystal structure
Gold
Graphene
Immunosensors
Nanocomposites
Nanoparticles
Self-assembled monolayers
Self-assembly
Sensors
Voltammetry
X-ray diffraction
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Summary:An effective way of monitoring the biomarker is with electrochemical sensor studies. In this work, it was formed using electrochemical deposition of high conductivity gold nanoparticles (AuNPs) and an amine-functional reduced graphene oxide (NH2-RGO) nanocomposite. This technique not only reduced HAuCl4 and graphene oxide in situ but also improved the electrocatalytic performance. XRD, SEM, and FTIR analytical methods confirmed the size and structure of the AuNPs/NH2-RGO nanoparticle. As a result of XRD analysis, AuNPs/NH2-RGO crystal structure was formed. In addition, antibodies (Ab) were immobilized on the modified electrode surface using a self-assembled monolayer. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used to evaluate the interaction of Ab with antigen. SHBG detection had a dynamic linear range of 0.6–12 nmol/L and a limit of detection (LOD) of 0.0043 µM in enhanced sensor applications. The AuNPs/NH2-RGO based sensor has the potential to be a valuable tool in clinical diagnostic applications in the future.
ISSN:1022-5528
1572-9028
DOI:10.1007/s11244-023-01899-0