Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents

Objective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: Well-known reaction like Knoevenagel condensation and Cu (I) catalyzed azide-alkyne cycloaddition were used. MTT assay was used in anticancer activity. Autodoc...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2024-04, Vol.50 (2), p.282-292
Main Authors: Ramakrishna, B., Karthik, B., Kumar, B. Ashok, Kumar, T. Kranthi
Format: Article
Language:English
Subjects:
Addition polymerization
Alkynes
Anticancer properties
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Coumarin
Cycloaddition
Docking
Doxorubicin
Life Sciences
Organic Chemistry
Synthesis
Triazoles
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Summary:Objective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: Well-known reaction like Knoevenagel condensation and Cu (I) catalyzed azide-alkyne cycloaddition were used. MTT assay was used in anticancer activity. Autodock tools were used foe docking studies. Results and Discussion: The fourteen compounds were screened against A549 and NCI-H460 and compared with Doxorubicin. In addition to this tubulin polymerization inhibition assay and docking studies were performed on some active compounds. Conclusions: Synthesized some new 1,2,3-triazole hybrids and tested their anticancer activity and screened for binding interaction with tubulin. Some of the compounds were found active.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162024020109