Numerical study of photonic crystal fiber-based optical biosensor for detection of cervical cancer

• Published in: Journal of optics (New Delhi) 2024-04, Vol.53 (2), p.1155-1162
• Main Authors: Srivastava, Dharini, Yadav, Sapana, Mishra, Adarsh Chandra, Singh, Sachin, Lohia, Pooja, Dwivedi, D. K.
• Format: Article
• Language: English
• Subjects: Biosensors; Cancer; Cervical cancer; Crystal fibers; Finite element method; Lasers; Optical Devices; Optics; Photonic crystals; Photonics; Physics; Physics and Astronomy; Refractivity; Research Article; Software; Terahertz frequencies; Waveguides
• ISSN: 0972-8821; 0974-6900
• DOI: 10.1007/s12596-023-01254-2

The present study has been performed with the purpose of designing a highly sensitive biosensor for cervical cancer cell detection. The structure of the proposed design for biosensor includes a hollow core, four-quarter circular-type airholes spread through the cladding region, and Zeonex (R.I.-1.53) as background fiber material. Further, guiding properties of the proposed waveguide have been studied. The suggested photonic crystal fiber structure has been operated in the THz frequency regime. COMSOL Multiphysics 5.6a software based on finite element method and MATLAB 17b software have been used to examine various guiding properties of the sensor. Various performance parameters such as effective refractive index 1.3414, effective area 8.4733 × 10 −9 µm 2 , nonlinearity 9.9468W −1  km −1 , propagation constant 2.5703 × 10 −26 , relative sensitivity 78.68%, and confinement loss 5.1406 × 10 −26  cm −1 have been evaluated for cervical cancer cells. The simplified design reduces fabrication complexity and makes it cost-effective. It enhances the optical sensing capabilities of the proposed sensor model. The proposed design will add new opportunities in the field of bio photonics. Moreover, it leads to better applications in medical field for detecting and diagnosing cervical cancer cells disease.