Galactan induces macrophage M0 to M1 conversion to combat colon cancer

A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigati...

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Bibliographic Details
Published in:Food Science and Technology Research 2024, Vol.30(1), pp.75-82
Main Authors: Meng, Yue, Yang, Guang, Ren, Ai, Qu, Yunhe, Wang, Xue, Mayo, Kevin H., Zhou, Yifa, Song, Chengcheng
Format: Article
Language:English
Subjects:
antitumor effect
Bone marrow
Cancer
Cantharellus cibarius
Colon cancer
Colorectal cancer
Cytotoxicity
galactan
Macrophages
NF-κB protein
Toll-like receptors
Tumor necrosis factor-α
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Summary:A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.
ISSN:1344-6606
1881-3984
DOI:10.3136/fstr.FSTR-D-23-00039