An Immunohistochemical Study of Matrix Metalloproteinase 2 and 9 in the Left Ventricle of the Heart of Preterm Born Rats in the Late Period of Ontogenesis

Immunohistochemical detection of matrix metalloproteinase (MMP) 2 and 9 was carried out in the myocardium of the left ventricle of preterm born (21 and 21.5 days of pregnancy) and full-term (22 days of pregnancy) rats on days 42, 56, and 180 of the postnatal period of ontogenesis. The intensity of i...

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Bibliographic Details
Published in:Cell and tissue biology 2024, Vol.18 (1), p.66-71
Main Authors: Ivanova, V. V., Serebryakova, O. N., Erokhina, A. V., Nikonova, A. D., Milto, I. V.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Gelatinase A
Gelatinase B
Heart
Immunohistochemistry
Life Sciences
Matrix metalloproteinase
Metalloproteinase
Myocardium
Pregnancy
Premature birth
Ventricle
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Summary:Immunohistochemical detection of matrix metalloproteinase (MMP) 2 and 9 was carried out in the myocardium of the left ventricle of preterm born (21 and 21.5 days of pregnancy) and full-term (22 days of pregnancy) rats on days 42, 56, and 180 of the postnatal period of ontogenesis. The intensity of immunopositive staining was assessed semiquantitatively. Preterm birth leads to increased immunopositive reaction intensity to MMP-2 and MMP-9 in the wall of the left ventricle of the rat heart. An increase in the intensity of the positive reaction to MMP-2 in the left ventricle of the heart of rats is observed the earlier, the greater the degree of prematurity. The intensity of the positive reaction to MMP-9 in the left ventricle of the heart of male rats increases with increasing degree of prematurity. An increase in the intensity of the positive reaction to MMP-2 and MMP-9 in the wall of the left ventricle of female rats due to preterm birth is determined exclusively in animals born on the 21st day of pregnancy, that is, with a greater degree of prematurity.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X24010036