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I2‐Promoted Cyclization of Thiocarbamates with Enaminones: a Protocol for the Synthesis of Polysubstituted Thiazol‐2(3H)‐ones
An I2‐promoted [3+2] cyclization reaction between thiocarbamates with enaminones has been developed for the synthesis of thiazol‐2(3H)‐one derivatives. This protocol involves C−S and C−N bond formation and exhibits good functional group tolerance. The reaction proceeded well at room temperature and...
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Published in: | Advanced synthesis & catalysis 2024-04, Vol.366 (7), p.1649-1653 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | An I2‐promoted [3+2] cyclization reaction between thiocarbamates with enaminones has been developed for the synthesis of thiazol‐2(3H)‐one derivatives. This protocol involves C−S and C−N bond formation and exhibits good functional group tolerance. The reaction proceeded well at room temperature and provided up to 98% yield of the desired products.Dedicated to Prof. Dr. Paul Knochel on the occasion of his retirement. |
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.202301047 |