A multifunctional cellulose nanocomposite with targeted fluorescence imaging and photothermal effects on breast cancer cells

Cellulose nanocrystals (CNCs) and polydopamine (PDA) have shown great application potential in the biomedical field due to their excellent biocompatibility. Using PDA@CNC as a carrier to construct functional nanocomposites for targeted fluorescence imaging of tumor cells and effective cancer treatme...

Full description

Saved in:
Bibliographic Details
Published in:Cellulose (London) 2024-04, Vol.31 (6), p.3645-3656
Main Authors: Hu, Guizhen, Ning, Juan, Wu, Tian, Li, Yuanjie, Nie, Yamin, Lei, Jiandu, Zhou, Yanmei
Format: Article
Language:English
Subjects:
Biocompatibility
Biomarkers
Bioorganic Chemistry
Breast cancer
Cell membranes
Cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Diagnosis
Fluorescence
Glass
Medical diagnosis
Medical imaging
MicroRNAs
Nanocomposites
Natural Materials
Organic Chemistry
Original Research
Photothermal conversion
Physical Chemistry
Polymer Sciences
Ribonucleic acid
RNA
Sustainable Development
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cellulose nanocrystals (CNCs) and polydopamine (PDA) have shown great application potential in the biomedical field due to their excellent biocompatibility. Using PDA@CNC as a carrier to construct functional nanocomposites for targeted fluorescence imaging of tumor cells and effective cancer treatment can expand the applications of CNCs in tumor diagnosis and treatment. Here, we conveniently modified microRNA-21 inhibitors (miRNAi) on PDA@CNC to construct a multifunctional nanocomposite (FAM-miRNAi@PDA@CNC) for achieving in situ fluorescence imaging of tumor biomarkers and photothermal effects to induce death of breast cancer cells. The overexpressed miRNA-21 in breast cancer cells hybridizes with FAM-miRNAi, triggering green fluorescence of FAM to recognize breast cancer cells. The rod-shaped morphology of FAM-miRNAi@PDA@CNC can effectively promote the endocytosis of FAM-miRNAi@PDA@CNC by the cell membrane. In addition, CNCs can stabilize the photothermal performance of PDA, and the photothermal conversion efficiency of PDA@CNC reached up to 61.66%, which will help FAM-miRNAi@PDA@CNC to achieve 70% apoptosis rate of breast cancer cells under 808 nm laser irradiation. The design of FAM-miRNAi@PDA@CNC provides a valuable pathway for CNCs utilization in biomedicine and accurate diagnosis and treatment of breast cancer.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-024-05830-y