Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

Caloric restriction is an effective means of extending a healthy lifespan. Fasting mimicking diet (FMD) is a growing pattern of caloric restriction. We found that FMD significantly prolonged the lifespan of prematurely aging mice. In naturally aging mice, FMD improved cognitive and intestinal health...

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Bibliographic Details
Published in:Food & function 2024-04, Vol.15 (8), p.453-4514
Main Authors: Wang, Qingyi, Xu, Jilei, Luo, Man, Jiang, Yao, Gu, Yanrou, Wang, Qiwen, He, Jiamin, Sun, Yong, Lin, Yifeng, Feng, Lijun, Chen, Shujie, Hou, Tongyao
Format: Article
Language:English
Subjects:
Aging
Cognition
Cognitive ability
Composition
Diet
Dietary restrictions
Digestive system
Fasting
Gastrointestinal tract
Immunological memory
Intestinal microflora
Intestine
Lamina propria
Life span
Lymphocytes
Lymphocytes T
Memory cells
Microbiota
Microorganisms
Mimicry
rRNA 16S
Senescence
Sequences
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Summary:Caloric restriction is an effective means of extending a healthy lifespan. Fasting mimicking diet (FMD) is a growing pattern of caloric restriction. We found that FMD significantly prolonged the lifespan of prematurely aging mice. In naturally aging mice, FMD improved cognitive and intestinal health. Through a series of behavioral experiments, we found that FMD relieved anxiety and enhanced cognition in aged mice. In the intestine, the FMD cycles enhanced the barrier function, reduced senescence markers, and maintained T cell naïve-memory balance in the lamina propria mucosa. To further explore the causes of immune alterations, we examined changes in the stool microbiota using 16S rRNA sequencing. We found that FMD remodeled gut bacterial composition and significantly expanded the abundance of Lactobacillus johnsonii . Our research revealed that FMD has in-depth investigative value as an anti-aging intervention for extending longevity and improving cognition, intestinal function, and gut microbiota composition. FMD prolongs life, improves cognition and slows the ageing of the intestines. Microbiota and gut immunity may play a role.
ISSN:2042-6496
2042-650X
DOI:10.1039/d4fo00483c