Synthesis of Spiro[indole-3,2′-pyrrole]triones by the Reaction of Pyrrolobenzoxazepinetriones with Enaminoketone

The reaction of 3-aroylpyrrolo[1,2- a ][4,1]benzoxazepine-1,2,4-triones with 3-(cyclohexylamino)-5,5-dimethylcyclohex-2-en-1-one afforded 3′-aroyl-1-cyclohexyl-4′-hydroxy-1′-[2-(hydroxymethyl)phenyl]-6,6-dimethyl-6,7-dihydrospiro[indole-3,2′-pyrrole]-2,4,5′(1 H ,1′ H ,5 H )-triones. This reaction ca...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2024, Vol.60 (1), p.185-188
Main Authors: Maslivets, A. A., Dmitriev, M. V., Maslivets, A. N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Synthesis
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Summary:The reaction of 3-aroylpyrrolo[1,2- a ][4,1]benzoxazepine-1,2,4-triones with 3-(cyclohexylamino)-5,5-dimethylcyclohex-2-en-1-one afforded 3′-aroyl-1-cyclohexyl-4′-hydroxy-1′-[2-(hydroxymethyl)phenyl]-6,6-dimethyl-6,7-dihydrospiro[indole-3,2′-pyrrole]-2,4,5′(1 H ,1′ H ,5 H )-triones. This reaction can be regarded as a new method of synthesis of spiro[indole-3,2′-pyrrole] derivatives.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024010238