Synthesis and Biological Activity of Some New 1,3,4-Oxadiazoles Derived from Carboxylic Acids

A series of novel 2,2′-([1,1′-biphenyl]-4,4′-diyl)bis(1,3,4-oxadiazole) derivatives were synthesized starting from the corresponding carboxylic acids. The synthesized compounds were identified by spectral methods, including FT-IR and 1 H NMR. Their physical and toxicological properties were predicte...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2024, Vol.60 (1), p.164-172
Main Authors: Hamdan, I. A. A., Tomma, J. H.
Format: Article
Language:English
Subjects:
Biological activity
Carboxylic acids
Chemistry
Chemistry and Materials Science
E coli
Molecular docking
NMR
Nuclear magnetic resonance
Organic Chemistry
Oxadiazoles
Spectral methods
Synthesis
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Summary:A series of novel 2,2′-([1,1′-biphenyl]-4,4′-diyl)bis(1,3,4-oxadiazole) derivatives were synthesized starting from the corresponding carboxylic acids. The synthesized compounds were identified by spectral methods, including FT-IR and 1 H NMR. Their physical and toxicological properties were predicted in silico, and molecular docking study was performed. The prepared compounds were evaluated for their antibacterial activity against two gram-positive ( Bacillus subtilis , Staphylococcus aureus ) and two gram-negative ( Escherichia coli , Pseudomonas aeruginosa ) bacterial strains, as well as liver enzymes.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024010214