Synthesis and Antimicrobial and Analgesic Activity of Products of the Recyclization of 5-(Het)Aryl-4-(trifluoromethyl)furan-2,3-diones under the Action of Aromatic Amines

4-Substituted 5-hydroxy-5-(trifluoromethyl)dihydrofuran-2,3-diones were synthesized by the reaction of 5-substituted 4,4,4-trifluoroacetylfuran-2,3-diones with aromatic amines. The synthesized compounds exhibited the antibacterial and antinociceptive activity.

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Bibliographic Details
Published in:Russian journal of organic chemistry 2024-02, Vol.60 (2), p.221-230
Main Authors: Kozlova, E. P., Balandina, S. Y., Makhmudov, R. R., Lisovenko, N. Y.
Format: Article
Language:English
Subjects:
Amines
Chemical synthesis
Chemistry
Chemistry and Materials Science
Diketones
Organic Chemistry
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Summary:4-Substituted 5-hydroxy-5-(trifluoromethyl)dihydrofuran-2,3-diones were synthesized by the reaction of 5-substituted 4,4,4-trifluoroacetylfuran-2,3-diones with aromatic amines. The synthesized compounds exhibited the antibacterial and antinociceptive activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024020064