Experimental studies of semiautomatic cryoconservation process for biological tissue specimens

Local low-temperature effects on samples of sheep aorta were studied using an experimental apparatus serving as a prototype for a medical device for semi-automatic cryopreservation of biological tissue with the option of using a variety of cryoprotectants with regulation of coolant flow and temperat...

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Bibliographic Details
Published in:Biomedical engineering 2024-03, Vol.57 (6), p.387-390
Main Authors: Pushkarev, A. V., Burkov, I. A., Ivannikova, V. M., Saakyan, N. Yu, Krotov, A. S., Tsiganov, D. I.
Format: Article
Language:English
Subjects:
Alcohol
Aorta
Biological activity
Biomaterials
Biomedical and Life Sciences
Biomedicine
Cooling
Coronary vessels
Cryopreservation
Cryoprotectants
Cryoprotectors
Engineering
Experiments
Low temperature
Medical equipment
Medical technology
Phase transitions
Polydimethylsiloxane
Sheep
Temperature effects
Tissues
Viscosity
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Summary:Local low-temperature effects on samples of sheep aorta were studied using an experimental apparatus serving as a prototype for a medical device for semi-automatic cryopreservation of biological tissue with the option of using a variety of cryoprotectants with regulation of coolant flow and temperature. The effectiveness of cell preservation was assessed by histological examination. The results showed that use of polydimethylsiloxane as a cryoprotectant led to preservation of biological tissue and has prospects for further research in order to find optimal modes of semi-automatic cryopreservation.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-024-10341-y