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1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE
Abstract Introduction Sarcopenia is common in patients with hip fracture, but few studies have examined whether assessment of sarcopenia improves prediction of adverse post-operative outcomes. We examined whether sarcopenia, diagnosed using hand grip strength (HGS), could predict outcomes after hip...
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| Published in: | Age and ageing 2023-07, Vol.52 (Supplement_2) |
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| creator | Jaiswal, S K Prowse, J Chaplin, A Sinclair, N Langford, S Reed, M Sayer, A A Witham, M D Sorial, A K |
| description | Abstract
Introduction
Sarcopenia is common in patients with hip fracture, but few studies have examined whether assessment of sarcopenia improves prediction of adverse post-operative outcomes. We examined whether sarcopenia, diagnosed using hand grip strength (HGS), could predict outcomes after hip fracture.
Methods
Routinely collected data from the National Hip Fracture Database were combined with locally collected HGS data from a high-volume orthopaedic trauma unit. Patients aged ≥65years with surgically managed, non-pathological hip fracture with grip strength measured on admission were included. The European Working Group on Sarcopenia in Older People (EWGSOP2) thresholds were used to identify patients with or without sarcopenia; those unable to complete grip strength testing were also included in analyses. Outcomes examined were 30-day and 120-day mortality, residential status and mobility, prolonged length of stay (>15 days) and post-operative delirium. Binary logistic regression models were used to examine prognostic value of HGS, and discriminant ability for the Nottingham Hip Fracture Score (NHFS) alone and on adding sarcopenia status were compared using c-statistics.
Results
We analysed data from 282 individuals; mean age 83.2 (SD 9.2) years; 200 (70.9%) were female. 99 (35.1%) patients had sarcopenia and 109 (38.7%) were unable to complete testing. Sarcopenia predicted higher 120-day mortality (OR 13.0, 95%CI 1.7-101.1, p=0.014), but not 30-day mortality (OR 1.5, 95%CI 0.1-16.9, p=0.74). Patients unable to complete HGS testing had higher 30-day mortality (OR 13.5, 95%CI 1.8-103.8, p=0.012) and 120-day mortality (OR 34.5, 95%CI 4.6-258.7, p |
| doi_str_mv | 10.1093/ageing/afad104.068 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3049090680</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ageing/afad104.068</oup_id><sourcerecordid>3049090680</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1090-d9c71b7de98e53ece12ee59e2ef1f1a2f6aebe39e32c9db14a9277a99729fb393</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EEqXwA6wssTb1Iy8vozQvKdRR4tKl5SRO1QqaktAFf49R-gGsRiOde-_MBeCZ4FeCOVvpvTmc9ivd645g5xV7wQ1YEMcLEA2YcwsWGGOKsE_5PXiYpqNdiUvoAuyI43KYhZt1WuUlrGUVb1KZwbCGISyreJ1HUlRQJLAUtUSijKtQ5u8xFFsZibe4hokoCrHLNynMrEFShZHcVvEjuOv1x2SernMJtkksowwVIs2jsECtvRujjrc-afzO8MC4zLSGUGNcbqjpSU807T1tGsO4YbTlXUMczanva87tJ33DOFuCl9n3PA5fFzN9q-NwGU82UjHscJvhBdhSdKbacZim0fTqPB4-9fijCFZ_Baq5QHUtUFmVFaFZNFzO_-F_AVbSbY8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3049090680</pqid></control><display><type>article</type><title>1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Oxford Journals Online</source><creator>Jaiswal, S K ; Prowse, J ; Chaplin, A ; Sinclair, N ; Langford, S ; Reed, M ; Sayer, A A ; Witham, M D ; Sorial, A K</creator><creatorcontrib>Jaiswal, S K ; Prowse, J ; Chaplin, A ; Sinclair, N ; Langford, S ; Reed, M ; Sayer, A A ; Witham, M D ; Sorial, A K</creatorcontrib><description>Abstract
Introduction
Sarcopenia is common in patients with hip fracture, but few studies have examined whether assessment of sarcopenia improves prediction of adverse post-operative outcomes. We examined whether sarcopenia, diagnosed using hand grip strength (HGS), could predict outcomes after hip fracture.
Methods
Routinely collected data from the National Hip Fracture Database were combined with locally collected HGS data from a high-volume orthopaedic trauma unit. Patients aged ≥65years with surgically managed, non-pathological hip fracture with grip strength measured on admission were included. The European Working Group on Sarcopenia in Older People (EWGSOP2) thresholds were used to identify patients with or without sarcopenia; those unable to complete grip strength testing were also included in analyses. Outcomes examined were 30-day and 120-day mortality, residential status and mobility, prolonged length of stay (>15 days) and post-operative delirium. Binary logistic regression models were used to examine prognostic value of HGS, and discriminant ability for the Nottingham Hip Fracture Score (NHFS) alone and on adding sarcopenia status were compared using c-statistics.
Results
We analysed data from 282 individuals; mean age 83.2 (SD 9.2) years; 200 (70.9%) were female. 99 (35.1%) patients had sarcopenia and 109 (38.7%) were unable to complete testing. Sarcopenia predicted higher 120-day mortality (OR 13.0, 95%CI 1.7-101.1, p=0.014), but not 30-day mortality (OR 1.5, 95%CI 0.1-16.9, p=0.74). Patients unable to complete HGS testing had higher 30-day mortality (OR 13.5, 95%CI 1.8-103.8, p=0.012) and 120-day mortality (OR 34.5, 95%CI 4.6-258.7, p<0.001). Sarcopenia status did not significantly improve discrimination for mobility but improved prediction of 120-day residential status (c-statistic 0.89 [95%CI 0.85-0.94] for NHFS+sarcopenia vs 0.82 [95%CI 0.76-0.87] for NHFS alone) and post-operative delirium (c-statistic 0.91 [95%CI 0.87-0.94] vs 0.78 [95%CI 0.73-0.84]).
Conclusions
Sarcopenia assessment via HGS testing may provide additional prognostic information to existing risk scores in older patients with hip fracture.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afad104.068</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Delirium ; Discrimination ; Fractured hips ; Fractures ; Grip strength ; Hip ; Hip joint ; Length of stay ; Medical prognosis ; Mobility ; Mortality ; Older people ; Regression analysis ; Risk assessment ; Sarcopenia ; Tests ; Thresholds</subject><ispartof>Age and ageing, 2023-07, Vol.52 (Supplement_2)</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,30976</link.rule.ids></links><search><creatorcontrib>Jaiswal, S K</creatorcontrib><creatorcontrib>Prowse, J</creatorcontrib><creatorcontrib>Chaplin, A</creatorcontrib><creatorcontrib>Sinclair, N</creatorcontrib><creatorcontrib>Langford, S</creatorcontrib><creatorcontrib>Reed, M</creatorcontrib><creatorcontrib>Sayer, A A</creatorcontrib><creatorcontrib>Witham, M D</creatorcontrib><creatorcontrib>Sorial, A K</creatorcontrib><title>1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE</title><title>Age and ageing</title><description>Abstract
Introduction
Sarcopenia is common in patients with hip fracture, but few studies have examined whether assessment of sarcopenia improves prediction of adverse post-operative outcomes. We examined whether sarcopenia, diagnosed using hand grip strength (HGS), could predict outcomes after hip fracture.
Methods
Routinely collected data from the National Hip Fracture Database were combined with locally collected HGS data from a high-volume orthopaedic trauma unit. Patients aged ≥65years with surgically managed, non-pathological hip fracture with grip strength measured on admission were included. The European Working Group on Sarcopenia in Older People (EWGSOP2) thresholds were used to identify patients with or without sarcopenia; those unable to complete grip strength testing were also included in analyses. Outcomes examined were 30-day and 120-day mortality, residential status and mobility, prolonged length of stay (>15 days) and post-operative delirium. Binary logistic regression models were used to examine prognostic value of HGS, and discriminant ability for the Nottingham Hip Fracture Score (NHFS) alone and on adding sarcopenia status were compared using c-statistics.
Results
We analysed data from 282 individuals; mean age 83.2 (SD 9.2) years; 200 (70.9%) were female. 99 (35.1%) patients had sarcopenia and 109 (38.7%) were unable to complete testing. Sarcopenia predicted higher 120-day mortality (OR 13.0, 95%CI 1.7-101.1, p=0.014), but not 30-day mortality (OR 1.5, 95%CI 0.1-16.9, p=0.74). Patients unable to complete HGS testing had higher 30-day mortality (OR 13.5, 95%CI 1.8-103.8, p=0.012) and 120-day mortality (OR 34.5, 95%CI 4.6-258.7, p<0.001). Sarcopenia status did not significantly improve discrimination for mobility but improved prediction of 120-day residential status (c-statistic 0.89 [95%CI 0.85-0.94] for NHFS+sarcopenia vs 0.82 [95%CI 0.76-0.87] for NHFS alone) and post-operative delirium (c-statistic 0.91 [95%CI 0.87-0.94] vs 0.78 [95%CI 0.73-0.84]).
Conclusions
Sarcopenia assessment via HGS testing may provide additional prognostic information to existing risk scores in older patients with hip fracture.</description><subject>Delirium</subject><subject>Discrimination</subject><subject>Fractured hips</subject><subject>Fractures</subject><subject>Grip strength</subject><subject>Hip</subject><subject>Hip joint</subject><subject>Length of stay</subject><subject>Medical prognosis</subject><subject>Mobility</subject><subject>Mortality</subject><subject>Older people</subject><subject>Regression analysis</subject><subject>Risk assessment</subject><subject>Sarcopenia</subject><subject>Tests</subject><subject>Thresholds</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqNkMtOwzAQRS0EEqXwA6wssTb1Iy8vozQvKdRR4tKl5SRO1QqaktAFf49R-gGsRiOde-_MBeCZ4FeCOVvpvTmc9ivd645g5xV7wQ1YEMcLEA2YcwsWGGOKsE_5PXiYpqNdiUvoAuyI43KYhZt1WuUlrGUVb1KZwbCGISyreJ1HUlRQJLAUtUSijKtQ5u8xFFsZibe4hokoCrHLNynMrEFShZHcVvEjuOv1x2SernMJtkksowwVIs2jsECtvRujjrc-afzO8MC4zLSGUGNcbqjpSU807T1tGsO4YbTlXUMczanva87tJ33DOFuCl9n3PA5fFzN9q-NwGU82UjHscJvhBdhSdKbacZim0fTqPB4-9fijCFZ_Baq5QHUtUFmVFaFZNFzO_-F_AVbSbY8</recordid><startdate>20230721</startdate><enddate>20230721</enddate><creator>Jaiswal, S K</creator><creator>Prowse, J</creator><creator>Chaplin, A</creator><creator>Sinclair, N</creator><creator>Langford, S</creator><creator>Reed, M</creator><creator>Sayer, A A</creator><creator>Witham, M D</creator><creator>Sorial, A K</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20230721</creationdate><title>1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE</title><author>Jaiswal, S K ; Prowse, J ; Chaplin, A ; Sinclair, N ; Langford, S ; Reed, M ; Sayer, A A ; Witham, M D ; Sorial, A K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1090-d9c71b7de98e53ece12ee59e2ef1f1a2f6aebe39e32c9db14a9277a99729fb393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Delirium</topic><topic>Discrimination</topic><topic>Fractured hips</topic><topic>Fractures</topic><topic>Grip strength</topic><topic>Hip</topic><topic>Hip joint</topic><topic>Length of stay</topic><topic>Medical prognosis</topic><topic>Mobility</topic><topic>Mortality</topic><topic>Older people</topic><topic>Regression analysis</topic><topic>Risk assessment</topic><topic>Sarcopenia</topic><topic>Tests</topic><topic>Thresholds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaiswal, S K</creatorcontrib><creatorcontrib>Prowse, J</creatorcontrib><creatorcontrib>Chaplin, A</creatorcontrib><creatorcontrib>Sinclair, N</creatorcontrib><creatorcontrib>Langford, S</creatorcontrib><creatorcontrib>Reed, M</creatorcontrib><creatorcontrib>Sayer, A A</creatorcontrib><creatorcontrib>Witham, M D</creatorcontrib><creatorcontrib>Sorial, A K</creatorcontrib><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaiswal, S K</au><au>Prowse, J</au><au>Chaplin, A</au><au>Sinclair, N</au><au>Langford, S</au><au>Reed, M</au><au>Sayer, A A</au><au>Witham, M D</au><au>Sorial, A K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE</atitle><jtitle>Age and ageing</jtitle><date>2023-07-21</date><risdate>2023</risdate><volume>52</volume><issue>Supplement_2</issue><issn>0002-0729</issn><eissn>1468-2834</eissn><abstract>Abstract
Introduction
Sarcopenia is common in patients with hip fracture, but few studies have examined whether assessment of sarcopenia improves prediction of adverse post-operative outcomes. We examined whether sarcopenia, diagnosed using hand grip strength (HGS), could predict outcomes after hip fracture.
Methods
Routinely collected data from the National Hip Fracture Database were combined with locally collected HGS data from a high-volume orthopaedic trauma unit. Patients aged ≥65years with surgically managed, non-pathological hip fracture with grip strength measured on admission were included. The European Working Group on Sarcopenia in Older People (EWGSOP2) thresholds were used to identify patients with or without sarcopenia; those unable to complete grip strength testing were also included in analyses. Outcomes examined were 30-day and 120-day mortality, residential status and mobility, prolonged length of stay (>15 days) and post-operative delirium. Binary logistic regression models were used to examine prognostic value of HGS, and discriminant ability for the Nottingham Hip Fracture Score (NHFS) alone and on adding sarcopenia status were compared using c-statistics.
Results
We analysed data from 282 individuals; mean age 83.2 (SD 9.2) years; 200 (70.9%) were female. 99 (35.1%) patients had sarcopenia and 109 (38.7%) were unable to complete testing. Sarcopenia predicted higher 120-day mortality (OR 13.0, 95%CI 1.7-101.1, p=0.014), but not 30-day mortality (OR 1.5, 95%CI 0.1-16.9, p=0.74). Patients unable to complete HGS testing had higher 30-day mortality (OR 13.5, 95%CI 1.8-103.8, p=0.012) and 120-day mortality (OR 34.5, 95%CI 4.6-258.7, p<0.001). Sarcopenia status did not significantly improve discrimination for mobility but improved prediction of 120-day residential status (c-statistic 0.89 [95%CI 0.85-0.94] for NHFS+sarcopenia vs 0.82 [95%CI 0.76-0.87] for NHFS alone) and post-operative delirium (c-statistic 0.91 [95%CI 0.87-0.94] vs 0.78 [95%CI 0.73-0.84]).
Conclusions
Sarcopenia assessment via HGS testing may provide additional prognostic information to existing risk scores in older patients with hip fracture.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1093/ageing/afad104.068</doi></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Oxford Journals Online |
| subjects | Delirium Discrimination Fractured hips Fractures Grip strength Hip Hip joint Length of stay Medical prognosis Mobility Mortality Older people Regression analysis Risk assessment Sarcopenia Tests Thresholds |
| title | 1459 HANDGRIP STRENGTH AS A PREDICTOR OF POST-OPERATIVE OUTCOMES FOLLOWING HIP FRACTURE |
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