Pseudo-Symmetric Crystallization of Fluoroquinolone Derivatives with a Terpene Moiety

The tendency of two pinane derivatives of fluoroquinolone to crystallize with two independent molecules in the unit cell is revealed. In these molecules, the geometry of achiral fluoroquinolone moieties is mirror symmetric at the identical configuration of the pinnae core. Prostereogenic groups in t...

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Bibliographic Details
Published in:Journal of structural chemistry 2024-03, Vol.65 (3), p.546-560
Main Authors: Frantsuzova, L. V., Gerasimova, D. P., Gilfanov, I. R., Sudarikov, D. V., Nikitina, L. E., Lodochnikova, O. A.
Format: Article
Language:English
Subjects:
Atomic
Atomic/Molecular Structure and Spectra
Chemistry
Chemistry and Materials Science
Crystallization
Inorganic Chemistry
Molecular
Optical and Plasma Physics
Physical Chemistry
Solid State Physics
Symmetry
Unit cell
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Summary:The tendency of two pinane derivatives of fluoroquinolone to crystallize with two independent molecules in the unit cell is revealed. In these molecules, the geometry of achiral fluoroquinolone moieties is mirror symmetric at the identical configuration of the pinnae core. Prostereogenic groups in the bridge between the bicycloheptene and fluoroquinolone fragments support the mirror symmetry of the achiral moiety. They are organized by intra- and intermolecular interactions, oppositely to independent molecules.
ISSN:0022-4766
1573-8779
DOI:10.1134/S0022476624030107