Women with Gestational Diabetes Mellitus do not have compromised polyunsaturated fatty acid status

Pregnant women who develop pre-eclampsia (PE) and/or intra-uterine growth restriction (IUGR) have reduced polyunsaturated fatty acid (PUFA) status compared to healthy pregnancy(1). It is unknown if pregnant women diagnosed with Gestational Diabetes Mellitus (GDM), and their offspring, also have comp...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2024-04, Vol.83 (OCE1), Article E141
Main Authors: Meyer, B.J., Dekker-Nitert, M., Cortie, C., Freeman, D.J., Barrett, H.L.
Format: Article
Language:English
Subjects:
Arachidonic acid
Cord blood
Diabetes mellitus
Erythrocytes
Fatty acids
Fetuses
Gas chromatography
Genetic crosses
Gestational diabetes
Offspring
Placenta
Plasma
Polyunsaturated fatty acids
Pre-eclampsia
Pregnancy
Pregnancy complications
Synthesis
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Summary:Pregnant women who develop pre-eclampsia (PE) and/or intra-uterine growth restriction (IUGR) have reduced polyunsaturated fatty acid (PUFA) status compared to healthy pregnancy(1). It is unknown if pregnant women diagnosed with Gestational Diabetes Mellitus (GDM), and their offspring, also have compromised PUFA status. To determine if women with GDM, and their offspring, have altered PUFA status compared to healthy pregnancy. Pregnant women were recruited from Glasgow Scotland, and Brisbane, Australia from antenatal clinics for this cross sectional study. Third trimester maternal blood samples were collected after an overnight fast and cord blood samples were collected at delivery. Plasma fatty acids were analysed using gas chromatography from women with GDM (n = 37) and healthy pregnancies (n = 27) and their respective offspring (n = 31, from women with GDM, and n = 27 from healthy women). T-tests were used to determine significant differences between maternal with GDM and healthy pregnancy, as well as for their offspring and significance was set at p
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665124001599