Selective Organ‐Targeting Hafnium Oxide Nanoparticles with Multienzyme‐Mimetic Activities Attenuate Radiation‐Induced Tissue Damage (Adv. Mater. 19/2024)

Organ‐Targeting Radioprotective NanozymesUnlike commonly known radioenhancing similars, rationally designed HfO2 nanoparticles herein are surprisingly radioprotective and capable of selectively targeting top vulnerable normal organs to counteract off‐target toxicity during radiotherapy. Under CT ima...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-05, Vol.36 (19)
Main Authors: Liu, Dingxin, Cao, Fei, Xu, Zhifeng, Zhao, Chunhua, Liu, Zekun, Pang, Jiadong, Liu, Ze‐Xian, Moghiseh, Mahdieh, Butler, Anthony, Liang, Shaoxia, Fan, Weijun, Yang, Jiang
Format: Article
Language:English
Subjects:
Computed tomography
Hafnium oxide
Nanoparticles
Radiation damage
Radiation effects
Radiation therapy
Online Access:Get full text
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Summary:Organ‐Targeting Radioprotective NanozymesUnlike commonly known radioenhancing similars, rationally designed HfO2 nanoparticles herein are surprisingly radioprotective and capable of selectively targeting top vulnerable normal organs to counteract off‐target toxicity during radiotherapy. Under CT image guidance, the multienzyme‐mimetic agents can alleviate DNA damage and inflammation in mouse and rabbit models upon hazardous radiation exposure, resulting in prolonged survival. More details can be found in article number 2308098 by Weijun Fan, Jiang Yang, and co‐workers.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202470149