Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent‐Free Conditions

Comprehensive Summary The development of switchable solvent‐free multicomponent reactions to build high‐value‐added products is an important demand for organic synthesis. Herein, we detailed the successful implementation of a switchable strategy for the construction of diverse 4‐fluoroalkyl‐1,4‐dihy...

Full description

Saved in:
Bibliographic Details
Published in:Chinese journal of chemistry 2024-06, Vol.42 (12), p.1394-1398
Main Authors: Zuo, Wanqing, Zhu, Zhizhen, Cheng, Yu, Zuo, Lingling, Geng, Xiao, Li, Zhifang, Wang, Lei
Format: Article
Language:English
Subjects:
Amidines
Chemical reactions
Enaminones
Environmental chemistry
Fluorine chemistry
Heterocycles
Multicomponent reactions
Pyrimidines
Solvents
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Comprehensive Summary The development of switchable solvent‐free multicomponent reactions to build high‐value‐added products is an important demand for organic synthesis. Herein, we detailed the successful implementation of a switchable strategy for the construction of diverse 4‐fluoroalkyl‐1,4‐dihydropyrimidines and 4‐fluoroalkyl‐pyrimidines via a solvent/additive‐free [3 + 2 + 1] annulation, starting from readily available enamines, trifluoroacetaldehyde hydrate or 1‐ethoxy‐2,2‐difluoroethanol and amidines hydrochloride. This reaction conforms to the concept of green synthesis, and provides a new avenue to access valuable fluorinated heterocycles. A switchable strategy for the construction of diverse 4‐fluoroalkyl‐1,4‐dihydropyrimidines and 4‐fluoroalkyl‐pyrimidines via a solvent/additive‐free [3 + 2 + 1] annulation, starting from readily available enamines, trifluoroacetaldehyde hydrate or 1‐ethoxy‐2,2‐difluoroethanol and amidines hydrochloride has been developed.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202300725