Metal‐Catalyzed Oxidative C−H Bond Functionalization of 1,4‐Benzoxazinones

The present review shows metal‐catalyzed oxidative C(sp3)‐H/C(sp2)‐H bond functionalization of 1,4‐benzoxazinones by utilizing various substrates such as indoles, phosphites or phosphine oxides, malonate esters, and resorcinol, which lead to the formation of new C−C or C−P bonds. The metal catalysts...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2024-05, Vol.13 (5), p.n/a
Main Authors: Kumar, Shankar, Ravi, Rangnath, Sahu, Tanu, Jha, Vikesh Kumar, Baweja, Renu, Jha, Abadh Kishor
Format: Article
Language:English
Subjects:
1,4-Benzoxazinone
Ball milling
Couplings
dehydrogenative
Esters
functionalization
Hydrogen bonds
Indoles
Inorganic salts
Iron
Natural products
Oxidation
oxidative
Phosphine oxide
Substrates
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Summary:The present review shows metal‐catalyzed oxidative C(sp3)‐H/C(sp2)‐H bond functionalization of 1,4‐benzoxazinones by utilizing various substrates such as indoles, phosphites or phosphine oxides, malonate esters, and resorcinol, which lead to the formation of new C−C or C−P bonds. The metal catalysts used for these couplings include Fe, Cu, Ag, and Ru. This follows a strategy involving either the one‐electron oxidation process (OEO), ball milling technique, or photocatalytic process. The synthesized products in this method show usefulness in natural products, materials, agriculture, and medicinal chemistry. This review covers Metal‐Catalyzed Oxidative C(sp3)‐H/C(sp2)‐H Bond Functionalization Reactions on 1,4‐Benzoxazinones with different coupling partners like indoles, phosphite, phosphine oxides, malonate esters and resorcinol. The synthesized products have shown their application in natural products, materials, agriculture and medicinal chemistry.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202400028