A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography

High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluat...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2024-05, Vol.91 (2), p.335-341
Main Authors: Davletshin, R. R., Galeev, R. R., Aryslanov, I. R., Galeeva, E. V., Sedov, A. N.
Format: Article
Language:English
Subjects:
Amoxicillin
Analytical Chemistry
Atomic/Molecular Structure and Spectra
High performance liquid chromatography
Physics
Physics and Astronomy
Raman spectroscopy
Thermal degradation
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Summary:High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-024-01725-9