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Green Synthesis and Biological Evaluation of Some 1,2,4-Triazol-3-ones
A series of 1,2,4-triazol-3-one derivatives were synthesized by using conventional heating and microwave irradiation techniques. Microwave syntheses of the target compounds were carried out by using both a domestic microwave oven and a monomode microwave reactor. The results showed that the use of m...
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Published in: | Russian journal of organic chemistry 2024-03, Vol.60 (3), p.513-521 |
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Main Author: | |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | A series of 1,2,4-triazol-3-one derivatives were synthesized by using conventional heating and microwave irradiation techniques. Microwave syntheses of the target compounds were carried out by using both a domestic microwave oven and a monomode microwave reactor. The results showed that the use of microwave technique is advantageous in terms of time, low solvent loading, yield, and efficiency. The synthesized compounds were tested for their antioxidant and antiurease activities. The antioxidant activity was evaluated by using ABTS [2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt] radical scavenging and cupric ion reducing antioxidant capacity (CUPRAC) methods. Most of the compounds showed good antioxidant activity, especially compound
8d
showed an SC
50
value of 71.062±9.31 μM in comparison to Trolox used as standard (SC
50
= 210.04±16.22 μM). According to the urease inhibitory activity results, most of the compounds showed better activity than thiourea (IC
50
= 0.5027±0.0293 μM); in particular, compound
8a
exhibited an IC
50
value of 0.3070±0.0394 μM. |
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ISSN: | 1070-4280 1608-3393 |
DOI: | 10.1134/S1070428024030205 |