Nickel‐Catalyzed Intramolecular Dual Annulation Reaction of Alkyl Nitrile‐Containing 1,2,3‐Benzotriazin‐4(3H)‐ones: A Pathway to Access Diversely Polycyclic Quinazolinone Alkaloids

Herein, we report a nickel‐catalyzed intramolecular dual annulation reaction of alkyl nitrile‐containing 1,2,3‐benzotriazin‐4(3H)‐ones to synthesize polycyclic quinazolinones. This catalytic reaction can construct the core structure of polycyclic quinazolinone alkaloids; therefore, we also apply thi...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-05, Vol.366 (9), p.2130-2135
Main Authors: Thorat, Vijaykumar H., Huang, Yong‐Ran, Chao, Hao‐Yu, Hsieh, Jen‐Chieh
Format: Article
Language:English
Subjects:
Addition of Nitrile
Alkaloids
Chemical reactions
Chemical synthesis
Denitrogenative Reaction
Intramolecular Cyclization
Nickel
Nickel Catalysis
Organic chemistry
Polycyclic Quinazolinone
Quinazolinones
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Summary:Herein, we report a nickel‐catalyzed intramolecular dual annulation reaction of alkyl nitrile‐containing 1,2,3‐benzotriazin‐4(3H)‐ones to synthesize polycyclic quinazolinones. This catalytic reaction can construct the core structure of polycyclic quinazolinone alkaloids; therefore, we also apply this reaction as the critical step to access fifteen relevant alkaloids to demonstrate efficacy.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202301512