Synthesis of Benzothiazin‐4‐ones via PPh3‐Promoted Cyclization of Benzodithiol‐3‐ones and Amidines

A phosphine‐mediated cyclization of benzo[c][1,2]dithiol‐3‐ones and amidines is demonstrated herein. Triphenylphosphine was harnessed as the activating reagent to facilitate the ring‐opening of benzo[c][1,2]dithiol‐3‐ones via S−S bond cleavage. This PPh3‐Promoted cyclization reaction of benzo[c][1,2...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-05, Vol.366 (9), p.1978-1982
Main Authors: Liu, Xiaobing, Lv, Wenxin, Dong, Junjie, Liu, Zekai, Hu, Feng, Zhou, Chuncheng, Zhou, Yao
Format: Article
Language:English
Subjects:
Phosphines
Reagents
Substrates
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A phosphine‐mediated cyclization of benzo[c][1,2]dithiol‐3‐ones and amidines is demonstrated herein. Triphenylphosphine was harnessed as the activating reagent to facilitate the ring‐opening of benzo[c][1,2]dithiol‐3‐ones via S−S bond cleavage. This PPh3‐Promoted cyclization reaction of benzo[c][1,2]dithiol‐3‐ones enabled to forge a diverse array of 1,3‐benzothiazones in decent yields with wide substrate scope under mild conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202301504