A Comprehensive Review on Antibacterial, Anti‐Inflammatory and Analgesic Properties of Noble Metal Nanoparticles

• Published in: Particle & particle systems characterization 2024-05, Vol.41 (5), p.n/a
• Main Authors: Aswathy Waliaveettil, Felicia, Anila, Edathottiyil Issac
• Format: Article
• Language: English
• Subjects: Analgesics; antibacterial property; antioxidant property, biomedical applications; Biocompatibility; Biomedical materials; Homeostasis; Inflammation; Nanoparticles; Noble metals; Pain; pain management; precious metal nanoparticles; surface plasmon
• ISSN: 0934-0866; 1521-4117
• DOI: 10.1002/ppsc.202300162

Their health industry is facing challenges due to a rise in mortality rates brought on by various multi‐drug‐resistant bacterial strains. As a result, new and improvedantibacterial drugs are urgently needed. Similarly, when some unwanted foreign pathogensenter the cellular premises to disturb its homeostasis, inflammation develops as an immune reaction. However, these immune responses also become a double‐edged sword when the inflammatory reaction lasts for a long time, and pain is also linked to inflammatory responses. Inflammation and pain are both signs of tissue injury. Pain is,by definition, an unpleasant experience that ultimately interferes with their normalwell‐being. Hence, bacterial infection, inflammation, and pain need medical assistance to maintain homeostasis. Conventional medicines possess so many repercussive effects, which then demand a replacement with a less toxic and more efficient modern drug. In their review article, for the first time, they present recent advancements in biomedical applications such as the antimicrobial, anti‐inflammatory, and analgesic properties of noble metal nanoparticles. Noble metals have limited availability in the earth's crust. Hence, their physicochemical characterizations and applications are greatly limited. Still, there are some interesting research findings that offer a significant ray of hope for the health sector all over the world. This review article discusses the physiological details of bacterial infections, inflammatory responses and pain sensation, the mechanism of standard antimicrobial, anti‐inflammatory, and analgesic drugs available in the market and also the scope of noble metal nanoparticles as promising drugs in this field.