Novel injectable calcium-magnesium phosphate cement-based composites with piezoelectric properties: advancements in bone regeneration applications

Designing a novel injectable bone cement is an important approach to the success of bone healing in minimally invasive surgeries. As natural bone has a piezoelectric property, which is crucial in bone regeneration, this study focused on the development of a novel injectable composite bone cement wit...

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Bibliographic Details
Published in:Journal of materials science. Materials in electronics 2024-05, Vol.35 (15), p.1023, Article 1023
Main Authors: Sakar, Neslihan, Ziylan Albayrak, Aylin, Karakaya, Merve, Adem, Umut, Tansel, Tunay
Format: Article
Language:English
Subjects:
Barium titanates
Bone cements
Bone surgery
Calcium phosphates
Calcium zirconate
Characterization and Evaluation of Materials
Chemistry and Materials Science
Composite materials
Compressive strength
Dielectric properties
Injectability
Magnesium phosphate
Materials Science
Optical and Electronic Materials
Orthopedics
Particle size distribution
Pastes
Piezoelectricity
Polymethyl methacrylate
Regeneration (physiology)
Zirconium
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Summary:Designing a novel injectable bone cement is an important approach to the success of bone healing in minimally invasive surgeries. As natural bone has a piezoelectric property, which is crucial in bone regeneration, this study focused on the development of a novel injectable composite bone cement with piezoelectric properties. For the composite composition, calcium and zirconium doped barium titanate (BCZT) was used for its piezoelectric property, while calcium phosphate and magnesium phosphate cement (CMPC) were preferred for its bone-like properties. In this framework, first BCZT, CMPC, and their composites were prepared, and their phase structures, particle size distributions, and piezoelectric and dielectric properties were investigated. Then, the composite bone cements were prepared by mixing CMPC with BCZT in three different ratios (20%, 30%, and 40%). Next, polysorbate 80 solution was added to the cement mixtures to prepare the injectable pastes. Finally, injectability, setting time, and compressive strength of the composites were assessed. As a result, the composite bone cement containing 30% BCZT has the potential to be used as an injectable bone cement in invasive orthopedic surgery.
ISSN:0957-4522
1573-482X
DOI:10.1007/s10854-024-12761-8