Correlating Receptor Status with Nottingham Prognostic Index in Breast Cancer

The biological behavior and prognosis of breast cancer is often unpredictable with a number of factors contributing to the outcome. Nottingham’s Prognostic Factor (NPI) takes into account the tumor size, nodal status, and histological grade of tumor. The receptor status considers the hormone recepto...

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Bibliographic Details
Published in:Indian journal of surgery 2024-04, Vol.86 (2), p.344-347
Main Authors: Gupta, Rohan, Khanna, Rahul, Kar, Amrita G., Khanna, Seema, Khanna, Siddharth, Meena, Ram Niwas
Format: Article
Language:English
Subjects:
Breast cancer
Cardiac Surgery
Medicine
Medicine & Public Health
Neurosurgery
Original Article
Pediatric Surgery
Plastic Surgery
Surgery
Thoracic Surgery
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Summary:The biological behavior and prognosis of breast cancer is often unpredictable with a number of factors contributing to the outcome. Nottingham’s Prognostic Factor (NPI) takes into account the tumor size, nodal status, and histological grade of tumor. The receptor status considers the hormone receptor and HER2 status. The aim of the study was to correlate the NPI score with the receptor status expression in Indian women with breast cancer. A total of 78 breast cancer patients who underwent upfront modified radical mastectomy were recruited. NPI score and receptor status assessment was done at histopathological examination of the specimen. Hormone receptor negative breast cancer tended to have a higher NPI score compared to hormone receptor positive patients. However, this difference did not achieve statistical significance. NPI score parameters except for the histological grade are a reflection of the duration or time span of the tumor. On the contrary, the receptor status is indicative of the tumor biology and not of its time duration. A scoring system which incorporates the three parameters of the NPI as well as the receptor status would be the best prognostic index as well as predictive regarding the choice of adjuvant therapy.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-023-03865-2