MR imaging characterization of pheochromocytoma: a comparison between typical and atypical tumor lesions

• Published in: Clinical and translational imaging : reviews in nuclear medicine and molecular imaging 2024, Vol.12 (3), p.337-346
• Main Authors: Maurea, Simone, Attanasio, Ludovica, Galatola, Roberta, Romeo, Valeria, Stanzione, Arnaldo, Camera, Luigi, Klain, Michele, Simeoli, Chiara, Modica, Roberta, Mascolo, Massimo, Aprea, Giovanni, Musella, Mario, Brunetti, Arturo
• Format: Article
• Language: English
• Subjects: Diagnostic Radiology; Diagnostic systems; Imaging; Interventional Radiology; Lesions; Magnetic resonance imaging; Medical and Radiation Physics; Medical imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Original Article; Radiology; Radiotherapy; Tumors
• ISSN: 2281-7565; 2281-5872; 2281-7565
• DOI: 10.1007/s40336-023-00608-x

Purpose The aim of this retrospective study was to compare the MRI features between typical and atypical pheochromocytomas (Pheos) to specifically illustrate MRI features of atypical tumors for helping tumor diagnosis. Methods A total of 22 patients (14 women and 8 men, median age: 53 years, age range: 25–82 years) with Pheos evaluated using a 3 T MRI scanner were retrospectively collected; in particular, all patients had one tumor lesion, except in two cases who had two and three lesions, respectively, for a total of 25 tumor lesions. Results Of the total 25 tumor lesions included in our series, 12 lesions were classified as typical for their classical appearance on MRI (T1 hypointensity, T2 hyperintensity, no signal drop on T1 out-of-phase, restricted diffusion and persistent contrast enhancement). Conversely, the other 13 tumors were classified as having atypical lesions because they did not show the MRI features observed in typical Pheos; in particular, 3 lesions showed signal intensity suggestive of tumor hemorrhagic changes , 2 lesions were totally cystic with an internal fluid–fluid level and a thin capsula, 3 lesions showed predominantly cystic signal intensity with residual solid tissue in the peripheral capsula, and the remaining 5 lesions appeared as rounded partially cystic lesions with associated areas of solid tissue. Conclusion The imaging characterization of typical Pheos may be performed using MRI with specific imaging features; however, atypical Pheos represents a diagnostic challenge using MRI; in these tumors, cystic, necrotic, hemorrhagic, or fat changes may occur; thus, diagnostic pitfalls should be taken into consideration for MRI interpretation of such tumor type in clinical practice.