Potential implications of polyphenolic compounds in neurodegenerative diseases

Neurodegenerative diseases are common chronic diseases related to progressive damage to the nervous system. Current neurodegenerative diseases present difficulties and despite extensive research efforts to develop new disease-modifying therapies, there is still no effective treatment for halting the...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2024, Vol.64 (16), p.5491-5514
Main Authors: Shi, Ruidie, Gao, Daili, Stoika, Rostyslav, Liu, Kechun, Sik, Attila, Jin, Meng
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Alzheimer's disease
Animals
Biological activity
Epilepsy
Epilepsy - drug therapy
Health promotion
Humans
Ischemia
ischemic stroke
Ischemic Stroke - drug therapy
Ischemic Stroke - prevention & control
Nervous system
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neuroprotection
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Organic compounds
Parkinson Disease - drug therapy
Parkinson's disease
Plants
Polyphenols
Polyphenols - pharmacology
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Summary:Neurodegenerative diseases are common chronic diseases related to progressive damage to the nervous system. Current neurodegenerative diseases present difficulties and despite extensive research efforts to develop new disease-modifying therapies, there is still no effective treatment for halting the neurodegenerative process. Polyphenols are biologically active organic compounds abundantly found in various plants. It has been reported that plant-derived dietary polyphenols may improve some disease states and promote health. Emerging pieces of evidence indicate that polyphenols are associated with neurodegenerative diseases. This review aims to overview the potential neuroprotective roles of polyphenols in most common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and ischemic stroke.
ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2022.2155106