Distribution of HCV genotype and single nucleotide polymorphisms (SNPs) of IL‐28B gene in HIV/HCV‐coinfected Thai populations

Introduction Hepatitis C virus (HCV) infection remains a major silent killer, worldwide, particularly in resource poor settings where treatment of hepatitis C is mainly impossible. Pegylated interferon‐α (PEG‐IFN) plus ribavirin (RBV) are the recommended treatment for patients with chronic hepatitis...

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Bibliographic Details
Published in:Journal of the International AIDS Society 2012-11, Vol.15 (S4), p.1-1
Main Authors: Avihingsanon, A, Mek‐A‐nantawat, W, Apornpong, T, Akkarathamrongsin, S, Ubolyam, S, Chomhong, P, Tangkitvanich, P
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Genotype & phenotype
Genotypes
Hepatitis
Hepatitis C
HIV
Human immunodeficiency virus
Interferon
Phylogenetics
Polymerase chain reaction
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Summary:Introduction Hepatitis C virus (HCV) infection remains a major silent killer, worldwide, particularly in resource poor settings where treatment of hepatitis C is mainly impossible. Pegylated interferon‐α (PEG‐IFN) plus ribavirin (RBV) are the recommended treatment for patients with chronic hepatitis C genotype 2/3. Recent study revealed that treatment responses against HCV infection by PEG‐IFN and RBV are significantly associated with the single nucleotide polymorphisms (SNPs) of interleukin‐28B (IL‐28B) gene. There is limited data about the HCV genotype and SNPs of IL‐28B in HIV‐infected Thai population. Therefore, we aimed to investigate HCV genotype and the SNP patterns of the IL‐28B gene in our HIV/HCV coinfection. Methods Quantification of HCV RNA was done by a real‐time polymerase chain reaction assay (Abbott with lower limit of detection of
ISSN:1758-2652
1758-2652
DOI:10.7448/IAS.15.6.18420