High viral load, previous fosamprenavir use and more recent HIV diagnosis correlate with darunavir failure in salvage therapy in Sao Paulo, Brazil

Purpose of the study Efficacy of DRV‐containing regimen in antiretroviral‐experienced patients in Brazil is unknown. The aim of this study was to evaluate the prevalence and risk factors associated with virologic failure (VF) to DRV containing salvage regimen in experienced HIV‐infected patients in...

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Bibliographic Details
Published in:Journal of the International AIDS Society 2012-11, Vol.15 (S4), p.1-1
Main Authors: Schöntag, M, Tenore, S, Ferreira, P, Guinoza, J, Diaz, R
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral drugs
Care and treatment
Darunavir
Dosage and administration
Fosamprenavir
HIV
HIV patients
Human immunodeficiency virus
Measurement
Multivariate analysis
Mutation
Risk factors
Viremia
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Summary:Purpose of the study Efficacy of DRV‐containing regimen in antiretroviral‐experienced patients in Brazil is unknown. The aim of this study was to evaluate the prevalence and risk factors associated with virologic failure (VF) to DRV containing salvage regimen in experienced HIV‐infected patients in Sao Paulo and also determine the prevalence of DRV resistance associated mutations (RAM) in this population. Methods Retrospective study of 131 patients who started a DRV‐containing salvage regimen between 12/2007 to 12/2009 in 2 centers in Sao Paulo. Protease resistance mutations listed by 2011 IAS‐USA panel update were considered. Genotypic sensitivity score (GSS) was calculated for the proposed regimen using the 2008 Rega algorithm. We have assessed VF during 48 weeks of follow up and VF was defined as the failure to achieve viral suppression in 48 weeks or viral rebound after suppression. Stopping the use of DRV for any reason was also considered VF. Summary of results We analysed 131 patients, 71% male, median age 44y. More than half of the patients had a baseline CD4 cell count
ISSN:1758-2652
1758-2652
DOI:10.7448/IAS.15.6.18269