Incidence and risk factors of chronic renal disease in a cohort of Greek HIV‐1‐infected adults

• Published in: Journal of the International AIDS Society 2012-11, Vol.15 (S4), p.1-1
• Main Authors: Sakka, V, Bakoyannis, G, Chini, M, Gargalianos, P, Sambatakou, H, Antoniadou, A, Chrysos, G, Paparizos, V, Daikos, G, Katsarou, O, Touloumi, G, Lazanas, M
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Age; AIDS; Females; Gender; HIV; Human immunodeficiency virus; Kidney diseases; Laboratory tests; Renal function; Risk factors
• ISSN: 1758-2652; 1758-2652
• DOI: 10.7448/IAS.15.6.18310

Chronic kidney disease (CKD) in HIV‐infected patients is associated with both HIV and non‐HIV‐related factors. Initial renal dysfunction is silent and detectable only by laboratory tests such as the glomerular filtration rate (GFR) estimated by the Cockcroft‐Gault equation. Our objective was to assess possible risk factors for CKD in a cohort of Greek HIV‐1‐infected adults. Methods Patients in the AMACS (Athens Multicenter AIDS Cohort Study) cohort with at least two available creatinine values were enrolled in the study. Renal dysfunction was defined as eGFR below 90 mL/min/1.73 m2. The Kaplan‐Meier estimator and the Cox proportional hazards model were used to analyze the occurrence and predictors of renal dysfunction. Results A total of 1073 patients were enrolled in the study; 255 (23.76%) had baseline eGFR below 90 mL/min/1.73 m2 and were excluded. Characteristics of the study population: men 88.4%, MSM 62.6%, median baseline age, CD4+count and viral load were 32.6 years, 413 cells/µL and 3.77 log10 copies/mL, respectively. 240 (29.3%) patients experienced an eGFR decrease below 90 mL/min/1.73 m2 during follow‐up period. Older age, female gender, heterosexual mode of transmission, lower baseline eGFR (all p