Diagnostic Utility of D‐Dimer Concentrations in Dogs with Pulmonary Embolism

BACKGROUND: Pulmonary embolism (PE) is a complication of systemic disease in dogs. Antemortem diagnosis is challenging because of the lack of a confirmatory test. OBJECTIVES: To retrospectively determine the diagnostic utility of D‐dimer concentrations in dogs with necropsy‐confirmed PE. ANIMALS: Te...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary internal medicine 2013-11, Vol.27 (6), p.1646-1649
Main Authors: Epstein, S.E., Hopper, K., Mellema, M.S., Johnson, L.R.
Format: Article
Language:English
Subjects:
Animals
Biomarker
Coagulation
Dog Diseases - pathology
Dogs
Female
Fibrin Fibrinogen Degradation Products - analysis
Male
Predictive Value of Tests
Pulmonary Embolism - blood
Pulmonary Embolism - pathology
Pulmonary Embolism - veterinary
Pulmonary embolisms
Respiratory distress
Retrospective Studies
Sensitivity and Specificity
Thromboembolism
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Pulmonary embolism (PE) is a complication of systemic disease in dogs. Antemortem diagnosis is challenging because of the lack of a confirmatory test. OBJECTIVES: To retrospectively determine the diagnostic utility of D‐dimer concentrations in dogs with necropsy‐confirmed PE. ANIMALS: Ten dogs with PE confirmed at necropsy that had D‐dimer concentrations measured and 10 control dogs with D‐dimer concentrations available that lacked PE on necropsy. METHODS: The computerized medical record database was searched for dogs with necropsy‐confirmed PE that had D‐dimer concentrations measured at that visit. An age‐, sex‐, and breed‐matched control group was identified. Signalment, location of PE, and coagulation profiles were collected. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated using a D‐dimer concentration of 250 ng/mL. RESULTS: Coagulation profiles were not different between dogs with and without PE. Using 250 ng/mL as a cut‐off D‐dimer concentration, the sensitivity and specificity were 80 and 30%, respectively, for the diagnosis of PE. The NPV and PPV were 60 and 53.0%, respectively. D‐dimer concentration
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.12177