Base-promoted fused β-carboline formation from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts

A novel base-promoted fused β-carboline formation strategy from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts has been developed. In this cascade reaction, ammonium salts served as a convenient nitrogen source and simultaneously played an important role in selectivity control, whi...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2024-06, Vol.11 (13), p.3583-3588
Main Authors: Chen, Jinjin, Zhang, Yu, Liu, Xinping, Liu, Kang, Wu, Junting, Peng, Xinlei, Guo-Jun, Deng
Format: Article
Language:English
Subjects:
Aldehydes
Ammonium
Ammonium salts
Cascade chemical reactions
Salts
Online Access:Get full text
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Summary:A novel base-promoted fused β-carboline formation strategy from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts has been developed. In this cascade reaction, ammonium salts served as a convenient nitrogen source and simultaneously played an important role in selectivity control, which can efficiently afford two different types of β-carbolines in satisfactory yields.
ISSN:2052-4110
2052-4110
DOI:10.1039/d4qo00551a