Synthesis of Spiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidines] by Reaction of Pyrrolobenzoxazinetriones with 6-Amino-1,3-dimethyluracil

3-Aroylpyrrolo[2,1- c ][1,4]benzoxazine-1,2,4-triones reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1 H ,3 H )-diones to give 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo­[2,3- d ]pyrimidine]-2′,4′,5,6′(1 H ,1′ H ,3′ H ,7′ H )-tetraones. The product structure was co...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2024-04, Vol.60 (4), p.632-637
Main Authors: Kobelev, A. I., Dmitriev, M. V., Maslivets, A. N.
Format: Article
Language:English
Subjects:
Benzoxazines
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pyrimidines
X ray analysis
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Summary:3-Aroylpyrrolo[2,1- c ][1,4]benzoxazine-1,2,4-triones reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1 H ,3 H )-diones to give 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo­[2,3- d ]pyrimidine]-2′,4′,5,6′(1 H ,1′ H ,3′ H ,7′ H )-tetraones. The product structure was confirmed by X-ray analysis. The described reaction provides a simple route to the difficultly accessible spiro[pyrrole-2,5′-pyrrolo[2,3- d ]­pyrimidine] heterocyclic system.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024040109