Synthesis, Characterization, and Cytotoxicity Evaluations of Silver–Zeolite Nanocomposite

Zeolites of natural origin are materials exhibiting many positive effects on the human body. Silver-modified zeolites have already been introduced as bactericidal agents, although studies dealing with their toxicity are insufficient. This work describes the synthesis of activated and silver-loaded B...

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Bibliographic Details
Published in:Coatings (Basel) 2024-06, Vol.14 (6), p.681
Main Authors: Kiradzhiyska, Denitsa, Batsalova, Tsvetelina, Dzhambazov, Balik, Milcheva, Nikolina, Gavazov, Kiril, Zahariev, Nikolay, Avdeev, Georgi, Simeonova, Stanislava
Format: Article
Language:English
Subjects:
Adsorption
Antimicrobial agents
Antioxidants
Biological activity
Composite materials
Dietary supplements
Diffraction
Electron microscopy
Fibroblasts
Investigations
Microscopy
Minerals
Morphology
Nanocomposites
Nanoparticles
Outdoor air quality
Pharmaceutical industry
Photocatalysis
Scavenging
Silver
Synthesis
Toxicity
X-rays
Zeolites
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Summary:Zeolites of natural origin are materials exhibiting many positive effects on the human body. Silver-modified zeolites have already been introduced as bactericidal agents, although studies dealing with their toxicity are insufficient. This work describes the synthesis of activated and silver-loaded Bulgarian zeolite using a simple wet impregnation method. Morphological characteristics and compositions of natural zeolite, activated zeolite, and Ag-nanocomposites were studied by the X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) methods. Silver loading is approximately 13 wt. %, with mean Ag particle size around 19 nm. Analyses of the samples included antioxidant activity assays based on ABTS radical scavenging ability and in vitro cytotoxicity tests with human normal fibroblasts and three adenocarcinoma cell lines. The experiments were performed with natural, activated, and Ag-modified zeolite in comparison to two commercial food supplements. Our results indicated moderate antioxidant activity of the tested samples. Silver-modified zeolite demonstrated cytotoxic effects against both tumor cells and normal fibroblasts, but the detected levels of inhibition were stronger against the adenocarcinoma cells, suggesting anti-tumor potential. The present article indicates a new aspect of Bulgarian natural zeolite and Ag-loaded zeolite biological activity. It highlights the need for detailed toxicity evaluations of Ag-nanocomposites prior to healthcare applications.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings14060681