Halogen‐Atom Transfer Enabled Catalytic Enantioselective Coupling to Chiral Trifluoromethylated Alkynes via Dual Nickel and Photocatalysis

With halogen‐atom transfer as an effective tool, a novel catalytic enantioselective protocol to generate chiral trifluoromethylated alkynes has been established by a cooperative photoredox and nickel catalysis system, providing a straightforward and modular route to access this type of product in go...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie 2024-07, Vol.136 (28), p.n/a
Main Authors: Lu, Shanya, Hu, Zihao, Wang, Dong, XU, Tao
Format: Article
Language:English
Subjects:
Alkynes
Catalysis
Couplings
Cross-Coupling
Electron transfer
Enantiomers
Halides
Halogen-Atom Transfer
Nickel
Photochemistry
Trifluoromethyl
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:With halogen‐atom transfer as an effective tool, a novel catalytic enantioselective protocol to generate chiral trifluoromethylated alkynes has been established by a cooperative photoredox and nickel catalysis system, providing a straightforward and modular route to access this type of product in good yields and enantioselectivities. The halogen‐atom transfer process is essential for the reaction and this novel strategy offers another promising way to utilize alkyl halides with highly negative reduction potentials. It firstly expands nickel‐catalyzed asymmetric reductive cross‐couplings of organohalides from the traditional single‐electron transfer to halogen‐atom transfer. With halogen‐atom transfer as an effective tool, a novel catalytic enantioselective protocol generating chiral trifluoromethylated alkynes with high yields and selectivities has been established. It uses a cooperative photoredox and nickel catalysis system, and expands the nickel‐catalysed asymmetric reductive cross‐coupling of organohalides from the traditional single‐electron transfer to halogen‐atom transfer.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202406064