Effectiveness of setarud (IMOD™) in attenuating gentamicin-induced nephrotoxicity in male rats

BackgroundGentamicin (GEN) can have serious adverse effects including nephrotoxicity. Setarud (IMOD™) is a new herbal drug with beneficial immune effects, obtained by mixing Tanacetum vulgare (tansy), Rosa canina and Urtica dioica (nettle) extracts as well as selenium, flavonoids and carotenes. This...

Full description

Saved in:
Bibliographic Details
Published in:Discover applied sciences 2024-07, Vol.6 (7), p.372, Article 372
Main Authors: Hormozi, Maryam, Ahmadvand, Hassan, Tavafi, Majid, Baharvand, Parastoo
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants
Attenuation
Bacterial infections
Body weight
Catalase
Clearances
Colorimetry
Creatinine
Density
Drug dosages
Effectiveness
Enzymes
Flavonoids
Gentamicin
Glutathione
Glutathione peroxidase
Herbal medicine
Immune clearance
Kidneys
Males
Necrosis
Oxidative stress
Peroxidase
Potassium
Proteins
Renal function
Selenium
Urea
Ureas
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundGentamicin (GEN) can have serious adverse effects including nephrotoxicity. Setarud (IMOD™) is a new herbal drug with beneficial immune effects, obtained by mixing Tanacetum vulgare (tansy), Rosa canina and Urtica dioica (nettle) extracts as well as selenium, flavonoids and carotenes. This novel study aims to evaluate the effectiveness of Setarud (IMOD™) in attenuating GEN-induced nephrotoxicity in male rats. Twenty-eight adult male Sprague Dawley rats (weighing 180–200 g) were randomly divided into four groups (7 rats in each group): Control, IMOD treated (20 mg/kg body weight), GEN treated (100 mg/kg body weight), and GEN + IMOD co-treated. Injections were done intraperitoneally for 12 days. Serum urea, creatinine (Cr), Cr clearance, malondialdehyde (MDA), reduced glutathione (GSH) level, and activities of antioxidant enzymes Peroxidase (POD), Catalase (CAT), and Glutathione peroxidase (GPx) were measured by the colorimetric method. Volume density of proximal convoluted tubule (PCT), tubular necrosis, tubular cast formation, and leukocytic infiltration were evaluated histopathologically.ResultsIn the GEN group, there were significantly higher serum urea, Cr, and MDA levels with lower Cr clearance, GSH levels, POD, GPx and CAT activities, and PCT volume density with presence of tubular necrosis compared to the control and IMOD groups (P 
ISSN:3004-9261
2523-3963
3004-9261
2523-3971
DOI:10.1007/s42452-024-06071-1