Synthesis and characterization of multi-targeted polymeric antibody-microparticle conjugates with controlled drug release

The presented experiments aimed to synthesize multi-targeted polymeric antibody-microparticles for the treatment of CD19+/CD20+ cancers. It is hypothesized that (1) targeting multiple tumor specific antigen (TSA) improves drug delivery by increasing binding in patients with low TSA expression and (2...

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Bibliographic Details
Published in:International journal of polymeric materials 2024-09, Vol.73 (14), p.1230-1237
Main Authors: Fernandez, Lucia, Oakes, Shannon, Cipullo, John, Moros, Cole, Hofman, Jenna, Comolli, Noelle
Format: Article
Language:English
Subjects:
Antibodies
B-cell malignancies
Biotin
Cancer
Chemical synthesis
Conjugates
controlled drug release
Glycolic acid
immunotherapy
Microparticles
polymeric microparticles
targeted cancer treatment
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Summary:The presented experiments aimed to synthesize multi-targeted polymeric antibody-microparticles for the treatment of CD19+/CD20+ cancers. It is hypothesized that (1) targeting multiple tumor specific antigen (TSA) improves drug delivery by increasing binding in patients with low TSA expression and (2) polymeric drug encapsulation enables controlled drug release. Protein-bound paclitaxel was successfully entrapped in biotin-avidin-antibody coated poly(lactic-co-glycolic acid) (PLGA). Targeting layers and antibody attachment did not negatively impacted drug release in vitro. Cell viability was reduced after administration in target cell lines. The presented technology forms a foundation for further investigation of multi-targeted polymeric antibody-microparticle conjugates capable of optimizing cancer treatment.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2023.2274609